Neurodegenerative diseases in domestic animals: a comparative review

Sisó, S; Hanzlícek, D; Fluehmann, G; Kathmann, I; Tomek, A; Papa, V; Vandevelde, M (2006). Neurodegenerative diseases in domestic animals: a comparative review. Veterinary journal, 171(1), pp. 20-38. Amsterdam: Elsevier 10.1016/j.tvjl.2004.08.015

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Neurodegenerative diseases are characterised by selective damage to specific neurons in the nervous system. Interest in such diseases in humans has resulted in considerable progress in the molecular understanding of these disorders in recent decades. Numerous neurodegenerative diseases have also been described in domestic animals but relatively little molecular work has been reported. In the present review, we have classified neurodegenerative disease according to neuroanatomical criteria. We have established two large groups, based on whether the neuronal cell body or its axon was primarily affected. Conditions such as motor neuron diseases, cerebellar degenerations and neuroaxonal dystrophies are discussed in terms of their clinical and neuropathological features. In the most studied disorders, we also present what is known about underlying pathomechanisms, and compare them with their human counterparts. The purpose of this review is to re-kindle interest in this group of diseases and to encourage veterinary researchers to investigate molecular mechanisms by taking advantage of current diagnostic tools.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research [discontinued]
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Siso, Silvia; Hanzlicek, David; Wyss, Gabriela; Challande, Iris; Tomek, Ales; Papa, Valentina and Vandevelde, Marc






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Date Deposited:

04 Oct 2013 14:45

Last Modified:

24 Oct 2019 04:51

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URI: (FactScience: 849)

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