Alterio, Daniela; Zaffaroni, Mattia; Bossi, Paolo; Dionisi, Francesco; Elicin, Olgun; Falzone, Andrea; Ferrari, Annamaria; Jereczek-Fossa, Barbara Alicja; Sanguineti, Giuseppe; Szturz, Petr; Volpe, Stefania; Scricciolo, Melissa (2024). Reirradiation of head and neck squamous cell carcinomas: a pragmatic approach-part I: prognostic factors and indications to treatment. La radiologia medica, 129(1), pp. 160-173. Springer 10.1007/s11547-023-01713-7
|
Text
s11547-023-01713-7.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
INTRODUCTION
Reirradiation (reRT) of locally recurrent/second primary tumors of the head and neck region is a potentially curative treatment for patients not candidate to salvage surgery. Aim of the present study is to summarize available literature on both prognostic factors and indications to curative reRT in this clinical setting.
MATERIALS AND METHODS
A narrative review of the literature was performed on two topics: (1) patients' selection according to prognostic factors and (2) dosimetric feasibility of reRT. Postoperative reRT and palliative intent treatments were out of the scope of this work.
RESULTS
Patient-tumor and treatment-related prognostic factors were analyzed, together with dosimetric parameters concerning target volume and organs at risk. Based on available evidence, a stepwise approach has been proposed aiming to provide a useful tool to identify suitable candidates for curative reRT in clinical practice. This was then applied to two clinical cases, proposed at the end of this work.
CONCLUSION
A second course of RT in head and neck recurrence/second primary tumors is a personalized approach that can be offered to selected patients only in centers with expertise and dedicated equipment following a multidisciplinary team discussion.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Eliçin, Olgun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1826-6983 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Sep 2023 15:18 |
Last Modified: |
25 Jan 2024 00:13 |
Publisher DOI: |
10.1007/s11547-023-01713-7 |
PubMed ID: |
37731151 |
Uncontrolled Keywords: |
Head and neck cancer Prognostic factors Reirradiation Squamous cell carcinoma Treatment |
BORIS DOI: |
10.48350/186481 |
URI: |
https://boris.unibe.ch/id/eprint/186481 |
Actions (login required)
 |
Edit item |