Antimicrobial effect of platelet-rich fibrin: A systematic review of in vitro evidence-based studies.

Moraschini, Vittorio; Miron, Richard J; Mourão, Carlos Fernando de Almeida Barros; Louro, Rafael Seabra; Sculean, Anton; da Fonseca, Luiz Afonso Morgenstern; Calasans Maia, Monica Diuana; Shibli, Jamil Awad (2024). Antimicrobial effect of platelet-rich fibrin: A systematic review of in vitro evidence-based studies. Periodontology 2000, 94(1), pp. 131-142. Blackwell 10.1111/prd.12529

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This systematic review (SR) aimed to evaluate the antimicrobial potential of different types of platelet-rich fibrin (PRF) often used in regenerative treatments. An electronic search was performed in four databases and in Gray literature for articles published until January, 2023. The eligibility criteria comprised in vitro studies that evaluated the antimicrobial effect of different types of PRF. For the analysis of the risk of bias within studies, the modified OHAT (Office of Health Assessment and Translation) tool was used. For the evaluation of the results, a qualitative critical analysis was carried out in the synthesis of the results of the primary studies. Sixteen studies published between 2013 and 2021 were included in this SR. The antimicrobial effects of PRF variations (PRF, injectable PRF [I-PRF], PRF with silver nanoparticles [agNP-PRF], and horizontal PRF [H-PRF]), were analyzed against 16 types of bacteria from the oral, periodontal, and endodontic environments. All types of PRF showed significant antimicrobial action, with the antibacterial efficacy being more expressive than the fungal one. The I-PRF, H-PRF, and agNP-PRF subtypes improve antimicrobial activity. According to the OHAT analysis, no study was classified as having a high risk of bias. Evidence suggests that PRF variations have significant antimicrobial activity, with bacterial action being greater than fungal. Evolutions such as I-PRF, H-PRF, and agNP-PRF improve antimicrobial activity. Future studies analyzing the clinical effect of these platelets are fundamental. This SR was registered in INPLASY under number INPLASY202340016.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Miron, Richard John, Sculean, Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0906-6713

Publisher:

Blackwell

Language:

English

Submitter:

Pubmed Import

Date Deposited:

25 Sep 2023 14:00

Last Modified:

18 May 2024 00:12

Publisher DOI:

10.1111/prd.12529

PubMed ID:

37740425

Uncontrolled Keywords:

PRF antimicrobials autologous platelet concentrates platelet-rich fibrin

BORIS DOI:

10.48350/186537

URI:

https://boris.unibe.ch/id/eprint/186537

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