Design of percutaneous transluminal coronary angioplasty balloon catheters.

Amstutz, C; Behr, J; Krebs, S; Haeberlin, A; Vogel, R; Zurbuchen, A; Burger, J (2023). Design of percutaneous transluminal coronary angioplasty balloon catheters. Biomedical engineering online, 22(1), p. 94. BioMed Central 10.1186/s12938-023-01155-2

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Eight commercially available percutaneous transluminal coronary angioplasty (PTCA), including semi-compliant and non-compliant balloons, have been assessed in detail on their tip, balloon, shaft, RX-Port, and hypotube design. Important performance characteristics such as tip deformation, balloon elongation, and deflation rate have been quantified.


Five catheters of each model were evaluated during various tests. The robustness of the tips was evaluated through compression, measuring any occurrence of damage. The longitudinal growth of the balloons was recorded during inflation up to Rated Burst Pressure (RBP). The forces required to move the catheter forward and retract it into the guide catheter were measured in a simulated use test setup. The deflation behavior was studied by measuring extracted contrast media over time. Furthermore, balloon compliance and catheter dimensions were investigated.


The outer dimensions of the catheter were found to be smallest at the hypotube (0.59-0.69 mm) and highest at the balloon, respectively, the crossing profile (0.9-1.2 mm). The tip diameter increased after compression by 1.7-22%. Cross-sections of the folded balloons revealed a tri- and two-fold, respectively. The measured balloon elongation ranged from 0.6 to 2.0 mm. After the inflation of the balloon, an increase in friction between the guide wire and the catheter was observed on four catheters. A maximum increase of 0.12 N to 1.07 N was found. Cross-sections of the RX-Port revealed a semicircular-shaped inflation lumen and a circular guide wire lumen. The measured deflation rate ranged from 0.004 to 0.013 µL/s, resulting in an estimated balloon deflation time of 10.2-28.1 s.


This study provides valuable insights into the design characteristics of RX PTCA balloon catheters, which can contribute to facilitating the development of improved catheter designs and enhancing clinical outcomes. Distinctions between SC and NC catheters, such as balloon performance and dimensions, are evident. It is important to note that no single catheter excels in all aspects, as each possesses unique strengths. Therefore, it is essential to consider individual intervention requirements when selecting a catheter. The research also identifies specific catheter weaknesses, such as reduced wall thickness, fringes at the tip, and reduced performance characteristics.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
08 Faculty of Science > School of Biomedical and Precision Engineering (SBPE)
08 Faculty of Science > School of Biomedical and Precision Engineering (SBPE) > Smart Surgical Instruments and Medical Devices

UniBE Contributor:

Amstutz, Cornelia Doreen, Behr, Jean-Marc, Häberlin, Andreas David Heinrich, Zurbuchen, Adrian, Burger, Jürgen


600 Technology > 610 Medicine & health




BioMed Central




Pubmed Import

Date Deposited:

25 Sep 2023 09:27

Last Modified:

29 Oct 2023 02:24

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PubMed ID:


Uncontrolled Keywords:

Balloon design Catheter design Hypotube Medical devices PTCA balloon catheter RX-Port




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