Nambiar, Malavika H; Liechti, Layko; Studer, Harald; Roy, Abhijit S; Seiler, Theo G; Büchler, Philippe (2023). Patient-specific finite element analysis of human corneal lenticules: An experimental and numerical study. Journal of the mechanical behavior of biomedical materials, 147(106141), p. 106141. Elsevier 10.1016/j.jmbbm.2023.106141
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The number of elective refractive surgeries is constantly increasing due to the drastic increase in myopia prevalence. Since corneal biomechanics are critical to human vision, accurate modeling is essential to improve surgical planning and optimize the results of laser vision correction. In this study, we present a numerical model of the anterior cornea of young patients who are candidates for laser vision correction. Model parameters were determined from uniaxial tests performed on lenticules of patients undergoing refractive surgery by means of lenticule extraction, using patient-specific models of the lenticules. The models also took into account the known orientation of collagen fibers in the tissue, which have an isotropic distribution in the corneal plane, while they are aligned along the corneal curvature and have a low dispersion outside the corneal plane. The model was able to reproduce the experimental data well with only three parameters. These parameters, determined using a realistic fiber distribution, yielded lower values than those reported in the literature. Accurate characterization and modeling of the cornea of young patients is essential to study better refractive surgery for the population undergoing these treatments, to develop in silico models that take corneal biomechanics into account when planning refractive surgery, and to provide a basis for improving visual outcomes in the rapidly growing population undergoing these treatments.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Musculoskeletal Biomechanics 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research |
UniBE Contributor: |
Nambiar, Malavika Harikrishnan, Liechti, Layko, Seiler, Günter Theodor Michael, Büchler, Philippe |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1878-0180 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Sep 2023 13:24 |
Last Modified: |
16 Oct 2023 00:16 |
Publisher DOI: |
10.1016/j.jmbbm.2023.106141 |
PubMed ID: |
37748318 |
BORIS DOI: |
10.48350/186603 |
URI: |
https://boris.unibe.ch/id/eprint/186603 |
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