Precolostral serology in calves born from Neospora-seropositive mothers

Staubli, Daniela; Sager, Heinz; Haerdi, Corinne; Haessig, Michael; Gottstein, Bruno (2006). Precolostral serology in calves born from Neospora-seropositive mothers. Parasitology research, 99(4), pp. 398-404. Berlin: Springer-Verlag 10.1007/s00436-006-0170-7

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The present study was designed to exploratively determine (a) how many healthy calves, born from seropositive mothers, were also precolostrally seropositive; (b) how many precolostrally negative calves became postcolostrally positive; and (c) in these calves, how the IgG1/IgG2 situation developed pre- and postcolostrally. All calves were born from mothers that were determined to be seropositive in a conventional Neospora caninum-ELISA and by immunoblotting. When the diagnostic performance of the conventional ELISA was compared with that of immunoblotting and an IgG1/IgG2-ELISA in the calves, the latter two exhibited a higher sensitivity: From a total of 15 precolostral calf sera, 7 were positive in the conventional ELISA (diagnostic sensitivity 47%) compared to 15 that were positive by immunoblotting (diagnostic sensitivity 100%) and 12 that were positive by the IgG1/IgG2-ELISA (diagnostic sensitivity 80%). With regard to IgG1/IgG2 findings in the dams, IgG2 appeared as the dominant subclass in the humoral immune response of adult cattle, while in calves, IgG1 appeared as the main prenatally/precolostrally reactive antibody isotype. Provided that precolostral seropositivity reflects postnatal persistent infection with N. caninum, we then postulate that, basically, all of our study calves born form N. caninum-seropositive mothers were prenatally infected with the parasite, and may, thus, all become members of the next transmitting generation.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Staubli, Daniela; Sager, Heinz and Gottstein, Bruno

ISSN:

0932-0113

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

26 Jun 2018 15:28

Publisher DOI:

10.1007/s00436-006-0170-7

PubMed ID:

16572335

Web of Science ID:

000240555100017

BORIS DOI:

10.7892/boris.18674

URI:

https://boris.unibe.ch/id/eprint/18674 (FactScience: 881)

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