Baroutsou, Vasiliki; Duong, Vu; Signorini, Alice; Saccilotto, Ramon; Ciorba, Florina M; Bürki, Nicole; Caiata-Zufferey, Maria; Ryu, Jai Min; Kim, Sung-Won; Lim, Myong Cheol; Monnerat, Christian; Zürrer-Härdi, Ursina; Kim, Jisun; Heinimann, Karl; Graffeo, Rossella; Park, Ji Soo; Rabaglio, Manuela; Chappuis, Pierre Olivier; Kim, Sue and Katapodi, Maria C (2023). Acceptability and Usability of the Family Gene Toolkit for Swiss and Korean Families Harboring BRCA1/BRAC2 Pathogenic Variants: A Web-Based Platform for Cascade Genetic Testing. Cancers, 15(18) MDPI AG 10.3390/cancers15184485
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The study adapted the Family Gene Toolkit and developed a customized web application for Swiss and Korean families harboring BRCA1 or BRCA2 pathogenic variants to support family communication of genetic testing results and promote cascade genetic testing among at-risk relatives. In the first step, narrative data from 68 women with BRCA1/BRCA2 pathogenic variants and clinician feedback informed a culturally sensitive adaptation of the content consistent with current risk management guidelines. In the second step, the Information Technology team developed the functions and the interface of the web application that will host the intervention. In the third step, a new sample of 18 women from families harboring BRCA1/BRCA2 pathogenic variants tested the acceptability and usability of the intervention using "think-aloud" interviews and a questionnaire. Participants expressed high levels of satisfaction with the intervention. They provided positive feedback for the information regarding active coping, strategies to enhance family communication, interactive elements, and illustrative stories. They reported that the information was useful and the web application was easy to navigate. Findings suggest that the Family Gene Toolkit is well-designed and can increase rates of cascade testing among at-risk relatives. Its efficacy will be tested in a subsequent randomized trial.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Rabaglio, Manuela Elena |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Oct 2023 11:21 |
Last Modified: |
02 Oct 2023 11:30 |
Publisher DOI: |
10.3390/cancers15184485 |
PubMed ID: |
37760455 |
Uncontrolled Keywords: |
HBOC Tier 1 genetic condition active coping decisional support family communication genetic counseling psychoeducational intervention |
BORIS DOI: |
10.48350/186772 |
URI: |
https://boris.unibe.ch/id/eprint/186772 |
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