Heidemeyer, Kristine; May Lee, Marco; Cazzaniga, Simone; Yawalkar, Nikhil; Naldi, Luigi (2023). Palmoplantar Pustulosis: A Systematic Review of Risk Factors and Therapies. Psoriasis - targets and therapy, 13, pp. 33-58. Dove Medical Press 10.2147/PTT.S400402
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PTT-400402-palmoplantar-pustulosis--a-systematic-review-of-risk-factors.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (2MB) | Preview |
Palmoplantar pustulosis (PPP) is a chronic, relapsing, inflammatory disease that can occur alone or in association with arthritis. There is still controversy about whether it should be separated from psoriasis or classified as pustular psoriasis. Furthermore, drug-induced paradoxical PPP is a special variant of PPP that differs from classic PPP in several ways. Treatment of PPP is still challenging, and there are a number of treatment-resistant cases. This review summarizes the risk factors for the development of PPP and the currently available treatment modalities. Female sex, smokers or ex-smokers, obesity, thyroid dysfunction, and treatment with a tumor necrosis factor (TNF)-α inhibitor have been identified as risk factors for the disease's development, severity, and course. Topical treatments and phototherapy are effective for some patients and are used as a first-line or adjuvant treatment modality. Conventional treatments including retinoids and fumaric acid show good effects and can increase the efficacy of treatment with psoralen + ultraviolet light therapy (PUVA). Ciclosporin is fast acting, but relapse mostly occurs immediately after cessation. TNF-α inhibitors are efficient, and an even better response can be achieved with IL-17 and IL-23 blockers as well as apremilast. The effect of Janus kinase inhibitors seems to be promising according to case reports, but further investigations with larger cohorts are needed.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Heidemeyer, Kristine, Cazzaniga, Simone, Yawalkar, Nikhil, Naldi, Luigi |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2230-326X |
Publisher: |
Dove Medical Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Oct 2023 09:25 |
Last Modified: |
04 Oct 2023 06:11 |
Publisher DOI: |
10.2147/PTT.S400402 |
PubMed ID: |
37772169 |
Uncontrolled Keywords: |
palmoplantar psoriasis pustulosis risk factors treatment |
BORIS DOI: |
10.48350/186798 |
URI: |
https://boris.unibe.ch/id/eprint/186798 |
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