Aeschlimann, Salome; Stettler, Philip; Schneider, André (2023). DNA segregation in mitochondria and beyond: insights from the trypanosomal tripartite attachment complex. Trends in biochemical sciences, 48(12), pp. 1058-1070. Elsevier Current Trends 10.1016/j.tibs.2023.08.012
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The tripartite attachment complex (TAC) of the single mitochondrion of trypanosomes allows precise segregation of its single nucleoid mitochondrial genome during cytokinesis. It couples the segregation of the duplicated mitochondrial genome to the segregation of the basal bodies of the flagella. Here, we provide a model of the molecular architecture of the TAC that explains how its eight essential subunits connect the basal body, across the mitochondrial membranes, with the mitochondrial genome. We also discuss how the TAC subunits are imported into the mitochondrion and how they assemble to form a new TAC. Finally, we present a comparative analysis of the trypanosomal TAC with open and closed mitotic spindles, which reveals conserved concepts between these diverse DNA segregation systems.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Aeschlimann, Salome Johanna, Stettler, Philip, Schneider, André |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
0968-0004 |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Oct 2023 16:08 |
Last Modified: |
12 Nov 2023 00:16 |
Publisher DOI: |
10.1016/j.tibs.2023.08.012 |
PubMed ID: |
37775421 |
Uncontrolled Keywords: |
Trypanosoma brucei basal body genome segregation mitochondrial genome inheritance mitosis mitotic spindle |
BORIS DOI: |
10.48350/186829 |
URI: |
https://boris.unibe.ch/id/eprint/186829 |
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