Long-term potentiation-like plasticity is retained during relapse in patients with Multiple Sclerosis.

Balloff, Carolin; Novello, Sveva; Stucke, Arved-Sebastian; Kathleen Janssen, Lisa; Heinen, Elisa; Johannes Hartmann, Christian; Meuth, Sven Günther; Schnitzler, Alfons; Penner, Iris-Katharina; Albrecht, Philipp; Groiss, Stefan Jun (2023). Long-term potentiation-like plasticity is retained during relapse in patients with Multiple Sclerosis. Clinical neurophysiology, 155, pp. 76-85. Elsevier 10.1016/j.clinph.2023.07.013

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OBJECTIVE

To investigate the degree of synaptic plasticity in Multiple Sclerosis (MS) patients during acute relapses compared to stable MS patients and healthy controls (HCs) and to analyze its functional relevance.

METHODS

Facilitatory quadripulse stimulation (QPS) was applied to the primary motor cortex in 18 acute relapsing and 18 stable MS patients, as well as 18 HCs. The degree of synaptic plasticity was measured by the change in motor evoked potential amplitude following QPS. Symptom recovery was assessed three months after relapse.

RESULTS

Synaptic plasticity was induced in all groups. The degree of induced plasticity did not differ between acute relapsing patients, HCs, and stable MS patients. Plasticity was significantly higher in relapsing patients with motor disability compared to relapsing patients without motor disability. In most patients (n = 9, 50%) symptoms had at least partially recovered three months after the relapse, impeding meaningful analysis of the functional relevance of baseline synaptic plasticity.

CONCLUSIONS

QPS-induced synaptic plasticity is retained during acute MS relapses. Subgroup analyses suggest that stabilizing metaplastic mechanisms may be more important to prevent motor disability but its functional relevance needs to be verified in larger, longitudinal studies.

SIGNIFICANCE

New insights into synaptic plasticity during MS relapses are provided.

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