Hahn, Rebecca T; Lawlor, Matthew K; Davidson, Charles J; Badhwar, Vinay; Sannino, Anna; Spitzer, Ernest; Lurz, Philipp; Lindman, Brian R; Topilsky, Yan; Baron, Suzanne J; Chadderdon, Scott; Khalique, Omar K; Tang, Gilbert H L; Taramasso, Maurizio; Grayburn, Paul A; Badano, Luigi; Leipsic, Jonathon; Lindenfeld, JoAnn; Windecker, Stephan; Vemulapalli, Sreekanth; ... (2023). Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints. European Heart Journal, 44(43), pp. 4508-4532. Oxford University Press 10.1093/eurheartj/ehad653
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Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. Historically, isolated tricuspid valve surgery has been associated with high in-hospital mortality rates, leading to the development of transcatheter treatment options. The aim of this first Tricuspid Valve Academic Research Consortium document is to standardize definitions of disease etiology and severity, as well as endpoints for trials that aim to address the gaps in our knowledge related to identification and management of patients with TR. Standardizing endpoints for trials should provide consistency and enable meaningful comparisons between clinical trials. A second Tricuspid Valve Academic Research Consortium document will focus on further defining trial endpoints and will discuss trial design options.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Windecker, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0195-668X |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Oct 2023 10:36 |
Last Modified: |
15 Nov 2023 00:15 |
Publisher DOI: |
10.1093/eurheartj/ehad653 |
PubMed ID: |
37793121 |
Uncontrolled Keywords: |
transcatheter treatment tricuspid regurgitation |
BORIS DOI: |
10.48350/186901 |
URI: |
https://boris.unibe.ch/id/eprint/186901 |
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