Valgimigli, Marco; Spirito, Alessandro; Sartori, Samantha; Angiolillo, Dominick J; Vranckx, Pascal; de la Torre Hernandez, Jose M; Krucoff, Mitchell W; Bangalore, Sripal; Bhatt, Deepak L; Campo, Gianluca; Cao, Davide; Chehab, Bassem M; Choi, James W; Feng, Yihan; Ge, Junbo; Hermiller, James; Kunadian, Vijay; Lupo, Sydney; Makkar, Raj R; Maksoud, Aziz; ... (2023). 1- or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI. JACC. Cardiovascular Interventions, 16(20), pp. 2498-2510. Elsevier 10.1016/j.jcin.2023.08.014
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BACKGROUND
The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients on long-term oral anticoagulation (OAC) therapy is still uncertain.
OBJECTIVES
The aim of this analysis was to assess the effects of 1- vs 3-month DAPT in patients with and those without concomitant OAC included in the XIENCE Short DAPT program.
METHODS
The XIENCE Short DAPT program enrolled patients with high bleeding risk who underwent successful PCI with a cobalt-chromium everolimus-eluting stent. DAPT was discontinued at 1 or 3 months in patients free from ischemic events and adherent to treatment. The effect of 1- vs 3-month DAPT was compared in patients with and those without OAC using propensity score stratification. The primary endpoint was all-cause death or any myocardial infarction (MI). The key secondary endpoint was Bleeding Academic Research Consortium (BARC) types 2 to 5 bleeding. Outcomes were assessed from 1 to 12 months after index PCI.
RESULTS
Among 3,364 event-free patients, 1,462 (43%) were on OAC. Among OAC patients, the risk for death or MI was similar between 1- and 3-month DAPT (7.4% vs 8.8%; adjusted HR: 0.74; 95% CI: 0.49-1.11; P = 0.139), whereas BARC types 2 to 5 bleeding was lower with 1-month DAPT (adjusted HR: 0.71; 95% CI: 0.51-0.99; P = 0.046). These effects were consistent in patients with and those without OAC (P for interaction = NS).
CONCLUSIONS
Between 1 and 12 months after PCI, 1-month compared with 3-month DAPT was associated with similar rates of all-cause death or MI and a reduced rate of BARC types 2 to 5 bleeding, irrespective of OAC treatment.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Valgimigli, Marco, Windecker, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1876-7605 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 Oct 2023 11:06 |
Last Modified: |
27 Oct 2023 00:17 |
Publisher DOI: |
10.1016/j.jcin.2023.08.014 |
PubMed ID: |
37804290 |
Uncontrolled Keywords: |
dual antiplatelet therapy everolimus-eluting stent high bleeding risk oral anticoagulant therapy percutaneous coronary intervention |
BORIS DOI: |
10.48350/186975 |
URI: |
https://boris.unibe.ch/id/eprint/186975 |
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