Ott, Muriel; Nagamany, Thanoosha; Zandi, Souska Sophie; Pichi, Francesco; Agarwal, Aniruddha; Carreño, Ester; Gupta, Vishali; Grewal, Dilraj S; Cunningham, Emmett T; Munk, Marion R (2023). Herpetic anterior uveitis following COVID-19 vaccines: a case series. Frontiers in medicine, 10, p. 1242225. Frontiers 10.3389/fmed.2023.1242225
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PURPOSE
To report a case series of herpetic uveitis following COVID-19 vaccinations.
METHODS
Demographic, clinical and treatment-related data of herpetic anterior uveitis cases was collected at five tertiary eye hospitals between January 2021 and June 2022. A retrospective database review at one of the centers comparing the number of cases of herpetic eye disease before and after the introduction of COVID-19 vaccination was performed as well.
RESULTS
Twenty-four patients (9 female, 15 male) with a mean age of 54 years (range 28-83 years) were diagnosed with herpetic uveitis, reporting an onset of symptoms 3-42 days after the first, second or third dose of COVID-19 vaccination. Median time between vaccination and onset of herpetic eye disease was 10 days (mean 12.7 ± 10.15 days) days. The administered vaccines were BNT162b2, mRNA-1273, BBIBP-CorV and Ad26.COV2.S. The cases included 11 HSV, 10 VZV and 1 CMV anterior uveitis, 2 were not further specified. There was an equal number of first episodes (n = 12, 50%) and recurrent episodes (n = 12, 50%). Response to established regimens was generally good. The retrospective database review revealed the exact same incidence of herpetic uveitis during the pandemic and ongoing vaccination compared to prior SARS-CoV-2.
CONCLUSION
This report includes 24 cases of herpetic anterior uveitis in a temporal relationship to various COVID-19 vaccines. This study supports the potential risk of herpetic eye disease following COVID-19 vaccines, but proof of a direct, causal relationship is missing.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Ott, Muriel, Nagamany, Thanoosha, Zandi, Souska Sophie, Munk, Marion |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2296-858X |
Publisher: |
Frontiers |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 Oct 2023 16:08 |
Last Modified: |
29 Oct 2023 02:25 |
Publisher DOI: |
10.3389/fmed.2023.1242225 |
PubMed ID: |
37809344 |
Uncontrolled Keywords: |
COVID-19 vaccines SARS-CoV-2 vaccination herpes zoster ophthalmicus herpetic eye disease keratitis mRNA vaccination ocular herpes simplex uveitis |
BORIS DOI: |
10.48350/187010 |
URI: |
https://boris.unibe.ch/id/eprint/187010 |
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