Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding - a human lactation study from the ConcePTION project.

Nordeng, Hedvig; Wegler, Christine; Lindqvist, Annika; Melander, Erik; Magnusson, Mikaela; Gandia, Peggy; Panchaud, Alice; Baranczewski, Pawel; Spigset, Olav (2024). Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding - a human lactation study from the ConcePTION project. Basic & clinical pharmacology & toxicology, 134(1), pp. 153-164. Wiley-Blackwell 10.1111/bcpt.13948

Preview	Text Nordeng_BasicClinPharmacolToxicol_2024.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (721kB) | Preview
Preview	Text Basic_Clin_Pharma_Tox_-_2023_-_Nordeng_-_Transfer_of_cetirizine_levocetirizine_into_human_breast_milk_and_estimation_of.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview

Data on drug transfer into human breast milk is sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least eight weeks postpartum and using cetirizine or its pure (R)-enantiomer levocetirizine were eligible to participate. Breast milk samples were collected at six predefined times during a dose interval (0, 2, 4, 8, 12 and 24 hours after drug intake) at steady state. Infant drug exposure was estimated by calculating the absolute infant dose (AID) and the weight-adjusted relative infant dose (RID). In total, 32 women were eligible for final inclusion, 31 women using cetirizine and one woman using levocetirizine. Means of the individual maximum and average cetirizine milk concentrations were 41.0 μg/L and 16.8 μg/L, respectively. Maximum concentrations occurred on average 2.4 hours after intake, and the mean half-life in milk was 7.0 h. Estimated AID and RID for cetirizine in a day were 2.5 μg/kg and 1.9%, respectively. The corresponding values for levocetirizine were 1.1 μg/kg and 1.9%. No severe adverse events were reported. Our findings demonstrate that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding.

Interest & Impact

Downloads

9 since deposited on 10 Oct 2023
9 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item