FedFTN: Personalized federated learning with deep feature transformation network for multi-institutional low-count PET denoising.

Zhou, Bo; Xie, Huidong; Liu, Qiong; Chen, Xiongchao; Guo, Xueqi; Feng, Zhicheng; Hou, Jun; Zhou, S Kevin; Li, Biao; Rominger, Axel; Shi, Kuangyu; Duncan, James S; Liu, Chi (2023). FedFTN: Personalized federated learning with deep feature transformation network for multi-institutional low-count PET denoising. Medical image analysis, 90(102993), p. 102993. Elsevier 10.1016/j.media.2023.102993

Text 1-s2.0-S1361841523002530-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (3MB)

Low-count PET is an efficient way to reduce radiation exposure and acquisition time, but the reconstructed images often suffer from low signal-to-noise ratio (SNR), thus affecting diagnosis and other downstream tasks. Recent advances in deep learning have shown great potential in improving low-count PET image quality, but acquiring a large, centralized, and diverse dataset from multiple institutions for training a robust model is difficult due to privacy and security concerns of patient data. Moreover, low-count PET data at different institutions may have different data distribution, thus requiring personalized models. While previous federated learning (FL) algorithms enable multi-institution collaborative training without the need of aggregating local data, addressing the large domain shift in the application of multi-institutional low-count PET denoising remains a challenge and is still highly under-explored. In this work, we propose FedFTN, a personalized federated learning strategy that addresses these challenges. FedFTN uses a local deep feature transformation network (FTN) to modulate the feature outputs of a globally shared denoising network, enabling personalized low-count PET denoising for each institution. During the federated learning process, only the denoising network's weights are communicated and aggregated, while the FTN remains at the local institutions for feature transformation. We evaluated our method using a large-scale dataset of multi-institutional low-count PET imaging data from three medical centers located across three continents, and showed that FedFTN provides high-quality low-count PET images, outperforming previous baseline FL reconstruction methods across all low-count levels at all three institutions.

Interest & Impact

Downloads

0 since deposited on 13 Oct 2023
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item