Cheng, Yang-Fan; Liu, Kun-Cheng; Yang, Tian-Mi; Xiao, Yi; Jiang, Qi-Rui; Huang, Jing-Xuan; Zhang, Sirui; Wei, Qian-Qian; Ou, Ru-Wei; Li, Chun-Yu; Gu, Xiao-Jing; Burgunder, Jean-Marc; Shang, Hui-Fang (2023). Factors influencing cognitive function in patients with Huntington's disease from China: A cross-sectional clinical study. Brain and Behavior, 13(11), e3258. Wiley 10.1002/brb3.3258
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Brain_and_Behavior_-_2023_-_Cheng_-_Factors_influencing_cognitive_function_in_patients_with_Huntington_s_disease_from_China.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (503kB) | Preview |
BACKGROUND AND AIM
Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the cognition status in a Chinese HD cohort and explore factors influencing the diverse cognitive domains.
METHODS
A total of 205 participants were recruited in the study with the assessment by neuropsychological batteries, including the mini-mental state examination (MMSE), Stroop test, symbol digit modalities test (SDMT), trail making test (TMT), verbal fluency test (VFT), and Hopkins verbal learning test-revised, as well as motor and psychiatric assessment. Pearson correlation and multiple linear regression models were applied to investigate the correlation.
RESULTS
Only 41.46% of patients had normal global function first come to our center. There was a significantly difference in MMSE, Stroop test, SDMT, TMT, and VFT across each stage of HD patients (p < .05). Apathy of PBA-s was correlated to MMSE, animal VFT and Stroop-interference tests performance. Severity of motor symptoms, functional capacity, age, and age of motor symptom onset were correlated to all neuropsychological scores, whereas education attainment and diagnostic delay were correlated to most neuropsychological scores except TMT. Severity of motor symptoms, functional capacity, and education attainment showed independent predicting effect (p < .05) in diverse cognitive domains.
CONCLUSION
Cognitive impairment was very common in Chinese HD patients at the first visit and worse in the patients in advanced phase. The severity of motor symptoms and functional capacity were correlated to the diverse cognitive domains.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Burgunder, Jean-Marc |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2162-3279 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Oct 2023 10:14 |
Last Modified: |
11 Nov 2023 00:16 |
Publisher DOI: |
10.1002/brb3.3258 |
PubMed ID: |
37849450 |
Uncontrolled Keywords: |
Chinese population Huntington's disease cognitive function influencing factors |
BORIS DOI: |
10.48350/187278 |
URI: |
https://boris.unibe.ch/id/eprint/187278 |
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