Rakic, Mia; Canullo, Luigi; Radovanovic, Sandro; Tatic, Zoran; Radunovic, Milena; Souedain, Assem; Weiss, Pierre; Struillou, Xavier; Vojvodic, Danilo (2024). Diagnostic value of VEGF in peri-implantitis and its correlation with titanium particles: A controlled clinical study. Dental materials, 40(1), pp. 28-36. Elsevier 10.1016/j.dental.2023.10.003
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OBJECTIVES
VEGF is prototypic marker of neovascularization, repeatedly proposed as intrinsic characteristic of peri-implantitis. This study aimed to assess pattern of VEGF in peri-implantitis, its correlation with titanium particles (TPs) and capacity as respective biomarker.
MATERIAL AND METHODS
Pathological specificity of VEGF was assessed in peri-implant granulations using immunohistochemistry, periodontal granulations represented Ti-free positive controls. VEGF was correlated to TPs, identified using scanning electron microscopy coupled with dispersive x-ray spectrometry. Diagnostic accuracy, sensitivity and specificity of VEGF were estimated in PICF specimens from peri-implantitis, peri-implant mucositis (PIM) and healthy peri-implant tissues (HI) using machine learning algorithms.
RESULTS
Peri-implantitis exhibited rich neovascular network with expressed density in contact zones toward neutrophil infiltrates without specific pattern variations around TPs, identified in all peri-implantitis specimens (mean particle size 8.9 ± 24.8 µm2; Ti-mass (%) 0.380 ± 0.163). VEGF was significantly more expressed in peri-implantitis (47,065 ± 24.2) compared to periodontitis (31,14 ± 9.15), and positively correlated with its soluble concentrations in PICF (p = 0.01). VEGF was positively correlated to all clinical endpoints and significantly increased in peri-implantitis compared to both PIM and HI, but despite high specificity (96%), its overall diagnostic capacity was average. Two patient clusters were identified in peri-implantitis, one with 8-fold higher VEGF values compared to HI, and second with lower values comparable to PIM.
SIGNIFICANCE
VEGF accurately reflects neovascularization in peri-implantitis that was expressed in contact zones toward implant surface without specific histopathological patter variation around TPs. VEGF answered requests for biomarker of peri-implantitis but further research is necessary to decrypt its exact underlying cause.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Canullo, Luigi |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0109-5641 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 Oct 2023 13:27 |
Last Modified: |
22 Dec 2023 00:14 |
Publisher DOI: |
10.1016/j.dental.2023.10.003 |
PubMed ID: |
37865576 |
Uncontrolled Keywords: |
Biomarker Diagnosis Machine learning algorithms Peri-implantitis Titanium particles VEGF |
BORIS DOI: |
10.48350/187354 |
URI: |
https://boris.unibe.ch/id/eprint/187354 |
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