Epp, Robert; Glück, Chaim; Binder, Nadine Felizitas; El Amki, Mohamad; Weber, Bruno; Wegener, Susanne; Jenny, Patrick; Schmid, Franca (2023). The role of leptomeningeal collaterals in redistributing blood flow during stroke. PLoS computational biology, 19(10), e1011496. Public Library of Science 10.1371/journal.pcbi.1011496
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Leptomeningeal collaterals (LMCs) connect the main cerebral arteries and provide alternative pathways for blood flow during ischaemic stroke. This is beneficial for reducing infarct size and reperfusion success after treatment. However, a better understanding of how LMCs affect blood flow distribution is indispensable to improve therapeutic strategies. Here, we present a novel in silico approach that incorporates case-specific in vivo data into a computational model to simulate blood flow in large semi-realistic microvascular networks from two different mouse strains, characterised by having many and almost no LMCs between middle and anterior cerebral artery (MCA, ACA) territories. This framework is unique because our simulations are directly aligned with in vivo data. Moreover, it allows us to analyse perfusion characteristics quantitatively across all vessel types and for networks with no, few and many LMCs. We show that the occlusion of the MCA directly caused a redistribution of blood that was characterised by increased flow in LMCs. Interestingly, the improved perfusion of MCA-sided microvessels after dilating LMCs came at the cost of a reduced blood supply in other brain areas. This effect was enhanced in regions close to the watershed line and when the number of LMCs was increased. Additional dilations of surface and penetrating arteries after stroke improved perfusion across the entire vasculature and partially recovered flow in the obstructed region, especially in networks with many LMCs, which further underlines the role of LMCs during stroke.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE) |
UniBE Contributor: |
Schmid, Franca Katharina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1553-734X |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 Oct 2023 08:57 |
Last Modified: |
03 Nov 2023 00:17 |
Publisher DOI: |
10.1371/journal.pcbi.1011496 |
PubMed ID: |
37871109 |
BORIS DOI: |
10.48350/187391 |
URI: |
https://boris.unibe.ch/id/eprint/187391 |
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