Hypoxia and lipid signaling

Huwiler, Andrea; Pfeilschifter, Josef (2006). Hypoxia and lipid signaling. Biological chemistry, 387(10-11), pp. 1321-8. Berlin: Walter de Gruyter 10.1515/BC.2006.165

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Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and respond to hypoxia by upregulating the expression of specific genes, which allows an adaptation to hypoxia-induced stress conditions. The modulation of cell signaling by hypoxia is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing environment. Cell signaling and adaptation processes are often accompanied by rapid and/or chronic remodeling of membrane lipids by activated lipases. This review highlights the bi-directional relation between hypoxia and lipid signaling mechanisms.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Huwiler, Andrea

ISSN:

1431-6730

ISBN:

17081102

Publisher:

Walter de Gruyter

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

25 Oct 2019 00:46

Publisher DOI:

10.1515/BC.2006.165

PubMed ID:

17081102

Web of Science ID:

000241788900004

BORIS DOI:

10.7892/boris.18743

URI:

https://boris.unibe.ch/id/eprint/18743 (FactScience: 981)

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