Adamantidis, Antoine R; de Lecea, Luis (2023). Sleep and the hypothalamus. Science, 382(6669), pp. 405-412. American Association for the Advancement of Science 10.1126/science.adh8285
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Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS (NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with cellular networks that support physiological and behavioral homeostasis. Here, we review the roles of sleep neurons of the hypothalamus in the homeostatic control of thermoregulation or goal-oriented behaviors during wakefulness. We address how hypothalamic circuits involved in opposing behaviors such as core body temperature and sleep compute conflicting information and provide a coherent vigilance state. Finally, we highlight some of the key unresolved questions and challenges, and the promise of a more granular view of the cellular and molecular diversity underlying the integrative role of the hypothalamus in physiological and behavioral homeostasis.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Adamantidis, Antoine Roger |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1095-9203 |
Publisher: |
American Association for the Advancement of Science |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Oct 2023 09:21 |
Last Modified: |
30 Oct 2023 20:30 |
Publisher DOI: |
10.1126/science.adh8285 |
PubMed ID: |
37883555 |
BORIS DOI: |
10.48350/187499 |
URI: |
https://boris.unibe.ch/id/eprint/187499 |
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