Lymphatic clearance of the human skin in patients with acute deep vein thrombosis using a novel fluorescent technique

Husmann, M J; Simon, R; Kovacevic, T; Gitzelmann, G; Koppensteiner, R; Amann-Vesti, B R (2006). Lymphatic clearance of the human skin in patients with acute deep vein thrombosis using a novel fluorescent technique. Lymphology, 39(3), pp. 127-31. Tucson, Ariz.: International Society of Lymphology

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The purpose of this study was to investigate lymphatic clearance of the human skin in patients with acute deep thrombosis of the femoral vein. In 13 patients with deep vein thrombosis and no other cause for swelling of the limbs, lymphatic clearance of the skin at the foot was measured. Ten microliters of fluorescein isothiocyanatedextran 150,000 were injected intradermally and the fluorescent light intensity of the deposit measured 10 min and 24 hours after injection by window densitometry. In addition, intralymphatic pressure was measured by the servo-nulling system. The results were compared with a sex- and age-matched control group. Fluorescent light intensity decreased by 23.8 +/- 12.3 arbitrary units or by a factor of 1.8 +/- 0.5 in patients with DVT after 24 hours, which was significantly less than in healthy controls (33.7 +/- 8.9 arbitrary units or by factor 5.0 +/- 4.1, p < 0.013). Intralymphatic pressure was not different between the two groups. These results indicate that lymphatic clearance is significantly reduced in the acute phase of deep venous thrombosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Husmann, Marc

ISSN:

0024-7766

ISBN:

17036633

Publisher:

International Society of Lymphology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

04 May 2014 23:13

PubMed ID:

17036633

Web of Science ID:

000240673500003

URI:

https://boris.unibe.ch/id/eprint/18785 (FactScience: 1023)

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