Stavropoulos, Andreas; Bellon, Benjamin; Pipenger, Benjamin; Andersen, Ole Z (2023). Two- and three-piece implants to boost data generation in preclinical in vivo research-A short technical report. Clinical and experimental dental research, 9(6), pp. 1004-1008. Wiley 10.1002/cre2.805
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Clinical_Exp_Dental_Res_-_2023_-_Stavropoulos_-_Two__and_three_piece_implants_to_boost_data_generation_in_preclinical_in.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (6MB) | Preview |
The purpose of this technical report is to present two novel experimental implant designs to boost data generation in preclinical in vivo research. Specifically, the report describes the rationale and the components of (1) a two-piece experimental implant suitable for a small animal platform (e.g., the rabbit femur/tibial epiphysis model), consisting of a threaded apical- and a coronal cylindrical piece, which is intended for collecting two types of biomechanical data, and (2) a three-piece experimental implant suitable for a large animal platform (e.g., the mini-pig mandible model), consisting of an apical "wound chamber", which allows the collection of histological/histomorphometrical data, and a middle threaded and coronal cylindrical piece, which also allow the collection of two types of biomechanical data. The increased volume of information generated from a single experiment in a small animal platform, using the proposed two-piece implant design, may assist in a more qualified decision-making process, on whether it is relevant to proceed to further assessment using a large animal platform. Furthermore, the increased volume of information generated in a single animal experiment either in a small or large animal platform, using the proposed two- and three-piece implants, respectively, likely decreases the number of animals otherwise needed for collecting the same information with standard one-piece implants and, thus, contributes to the reduction/refinement elements of the 3R principle.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > School of Dental Medicine |
UniBE Contributor: |
Stavropoulos, Andreas, Ole-Zoffmann, Andersen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2057-4347 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 Nov 2023 09:06 |
Last Modified: |
20 Dec 2023 00:15 |
Publisher DOI: |
10.1002/cre2.805 |
PubMed ID: |
37905711 |
Uncontrolled Keywords: |
biomechanical histology implants preclinical |
BORIS DOI: |
10.48350/188473 |
URI: |
https://boris.unibe.ch/id/eprint/188473 |
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