Effect of oral donepezil on intraocular pressure in normotensive Alzheimer patients

Estermann, Stephan; Daepp, Gian-Carlo; Cattapan-Ludewig, Katja; Berkhoff, Magdalena; Frueh, Beatrice E; Goldblum, David (2006). Effect of oral donepezil on intraocular pressure in normotensive Alzheimer patients. Journal of ocular pharmacology and therapeutics, 22(1), pp. 62-7. New York, N.Y.: Mary Ann Liebert 10.1089/jop.2006.22.62

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Donepezil, a selective acetylcholinesterase (AChE) inhibitor, has been shown to reduce intraocular pressure (IOP) in ocular normotensive rabbit eyes. The aim of this investigation was to evaluate the effect of oral donepezil on IOP and pupil diameter after mid-term oral treatment in normotensive persons. Thirty-two newly diagnosed Alzheimer patients with normal IOP and no further antiglaucomatous treatment were included in the study. IOP and pupil diameter were evaluated before and 4 weeks after daily intake of 5 mg donepezil. IOP and pupil diameter were significantly lower/smaller after 4 weeks of treatment. The mean IOP of all 63 eyes was 14.1 mmHg before and 12.8 mmHg after treatment (8.8% reduction). Mean pupil diameter constricted from 3.9 to 3.6 mm (-7.4%). These findings show that donepezil, and, possibly, other selective AChE inhibitors, can potentially be used to treat glaucoma. They are also known to have neuroprotective effects in Alzheimer's, and, therefore, might have an additional therapeutic benefit.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

Estermann, Stephan; Cattapan-Ludewig, Katja; Früh Epstein, Beatrice and Goldblum, David

ISSN:

1080-7683

ISBN:

16503777

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1089/jop.2006.22.62

PubMed ID:

16503777

Web of Science ID:

000235816300009

URI:

https://boris.unibe.ch/id/eprint/18849 (FactScience: 1102)

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