Prevalence of co-occurring conditions in children and adults with autism spectrum disorder: A systematic review and meta-analysis.

Micai, Martina; Fatta, Laura Maria; Gila, Letizia; Caruso, Angela; Salvitti, Tommaso; Fulceri, Francesca; Ciaramella, Antonio; D'Amico, Roberto; Del Giovane, Cinzia; Bertelli, Marco; Romano, Giovanna; Schünemann, Holger Jens; Scattoni, Maria Luisa (2023). Prevalence of co-occurring conditions in children and adults with autism spectrum disorder: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews, 155, p. 105436. Elsevier 10.1016/j.neubiorev.2023.105436

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This systematic review estimates the prevalence of co-occurring conditions (CCs) in children and adults with autism. A comprehensive search strategy consulting existing guidelines, diagnostic manuals, experts, carers, and autistic people was developed. PubMed and PsycInfo databases from inception to May 2022 were searched. PROSPERO registration: CRD42019132347. Two blind authors screened and extracted the data. Prevalence estimates for different CCs were summarized by using random effects models. Subgroup analyses were performed for age groups (children/adolescents vs adults) and study designs (population/registry-based vs clinical sample-based). Of 19,932 studies, 340 publications with about 590,000 participants were included and meta-analyzed to estimate the prevalence of 38-point prevalence, 27-lifetime, and 3 without distinction between point and lifetime prevalence. Point prevalence of developmental coordination disorder, sleep-wake problem, gastrointestinal problem, ADHD, anxiety disorder, overweight/obesity, feeding and eating disorder, elimination disorder, disruptive behavior, and somatic symptoms and related disorder were the most frequent CCs. Prevalence differed depending on the age group and study design. Knowing specific CCs linked to autism helps professional investigations and interventions for improved outcomes.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Del Giovane, Cinzia


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Pubmed Import

Date Deposited:

03 Nov 2023 14:12

Last Modified:

09 Dec 2023 00:15

Publisher DOI:


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Uncontrolled Keywords:

Autism Spectrum Disorder Co-occurring Condition Comorbidity Dual Diagnosis Frequency Incidence Meta-analysis Multimorbidity Prevalence Systematic review




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