Vitrectomy for juvenile uveitis: prognostic factors for the long-term functional outcome

Trittibach, P; Koerner, F; Sarra, G-M; Garweg, J G (2006). Vitrectomy for juvenile uveitis: prognostic factors for the long-term functional outcome. Eye, 20(2), pp. 184-190. London: Nature Publishing Group 10.1038/sj.eye.6701845

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PURPOSE: This study evaluated the long-term effect of pars plana vitrectomy (PPV) in children and adolescents with chronic uveitis on visual function, anatomical outcome, and the requirement of systemic treatment. Further, predictive preoperative factors associated with a beneficial visual outcome were assessed. METHODS: Retrospective review of 29 eyes of 23 consecutive paediatric and juvenile patients below 20 years of age with chronic uveitis who underwent a PPV for visually significant opacities in 25 eyes, vitreous haemorrhage in three eyes, and retinal detachment in one eye. The clinical diagnosis was chronic intermediate uveitis in 22 eyes and retinal vasculitis of different origin in seven eyes. RESULTS: LogMAR visual acuity improved from an average of 0.91 to 0.33 (P<0.001). Cystoid macular oedema (CME) was significantly reduced in eight of 10 eyes postoperatively (P=0.021). In the multiple regression analysis, a low preoperative logMAR visual acuity and the presence of a CME had a negative influence on the final logMAR visual acuity. Furthermore, the appearance of chronic uveitis relapses was significantly reduced from 15 eyes before to seven eyes after surgery (P=0.042). CONCLUSIONS: PPV has a beneficial effect on the course and the complications of chronic uveitis in paediatric and juvenile patients with respect to the anatomical and visual outcome. Preoperative logMAR visual acuity and clinically significant CME were the most accurate predictors for the functional outcome.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Trittibach, Peter; Sarra, Gian-Marco and Garweg, Justus

ISSN:

0950-222X

ISBN:

15803175

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

01 Dec 2015 09:51

Publisher DOI:

10.1038/sj.eye.6701845

PubMed ID:

15803175

Web of Science ID:

000235133200009

URI:

https://boris.unibe.ch/id/eprint/18862 (FactScience: 1116)

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