Grover's disease induced by cetuximab

Tscharner, Gion Gudench; Bühler, Sabine; Borner, Markus; Hunziker, Thomas (2006). Grover's disease induced by cetuximab. Dermatology, 213(1), pp. 37-9. Basel: Karger 10.1159/000092836

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A 71-year-old man exhibited an acute acneiform rash affecting the face and the upper trunk about 2 weeks after starting cetuximab, an epidermal growth factor (EGF) receptor antagonist treatment for metastatic colon cancer. The skin eruption faded after stopping cetuximab and applying topical corticosteroids. The reexposure to cetuximab 3 weeks later provoked a more extended relapse of the skin rash, which then clinically and histologically corresponded to transient acantholytic dermatosis . While the acneiform cutaneous side effects of the EGF receptor antagonists are interpreted as a result of the direct interference with pilosebaceous follicle homeostasis, in this case an acrosyringium-related pathogenesis might be postulated. Applying topical corticosteroids and emollients, the cetuximab therapy could be pursued.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Tscharner, Gion Gudench; Bühler, Sabine; Borner, Markus and Hunziker, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1018-8665

ISBN:

16778425

Publisher:

Karger

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

28 Jan 2015 12:26

Publisher DOI:

10.1159/000092836

PubMed ID:

16778425

Web of Science ID:

000238425000009

BORIS DOI:

10.7892/boris.18900

URI:

https://boris.unibe.ch/id/eprint/18900 (FactScience: 1168)

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