Postoperative radiation therapy for T1 and T2 primary parotid carcinoma: is it useful?

Zbären, Peter; Nuyens, Michel; Caversaccio, Marco; Greiner, Richard; Stauffer, Edouard (2006). Postoperative radiation therapy for T1 and T2 primary parotid carcinoma: is it useful? Otolaryngology - head and neck surgery, 135(1), pp. 140-3. Thousand Oaks, Calif.: Sage 10.1016/j.otohns.2006.03.007

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OBJECTIVE: The benefit of postoperative radiation for advanced primary parotid carcinoma has been reported previously, whereas studies to evaluate the usefulness of postoperative radiation for T1 and T2 parotid carcinomas have never been performed. STUDY DESIGN AND SETTING: Retrospective analysis on 58 previously untreated patients with T1 and T2 parotid carcinomas. In 34 patients, postoperative radiation was included in the treatment protocol and in 24 patients, no postoperative radiation was applied. RESULTS: A local recurrence was observed in 8 of 24 (33%) patients without and in 1 of 34 (3%) patients with postoperative radiation (P < 0.5). The 5-year actuarial and disease-free survival rate was 83% and 70% for patients without postoperative radiation and 93% and 92% for patients with postoperative radiation. CONCLUSION AND SIGNIFICANCE: Local recurrence was less often observed in patients with postoperative radiation. Nevertheless, prospective randomized studies are needed to confirm the usefulness of postoperative radiation in early carcinomas. EBM rating: B-3b.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
UniBE Contributor:	Zbären, Peter, Caversaccio, Marco, Greiner, Richard
ISSN:	0194-5998
ISBN:	16815199
Publisher:	Sage
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:46
Last Modified:	05 Dec 2022 14:14
Publisher DOI:	10.1016/j.otohns.2006.03.007
PubMed ID:	16815199
Web of Science ID:	000238824500027
URI:	https://boris.unibe.ch/id/eprint/18908 (FactScience: 1178)