Fate of inhaled particles after interaction with the lung surface

Gehr, Peter; Blank, Fabian; Rothen-Rutishauser, Barbara M (2006). Fate of inhaled particles after interaction with the lung surface. Paediatric respiratory reviews, 7 Suppl 1, S73-S75. London: Elsevier 10.1016/j.prrv.2006.04.169

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Inhaled particles may cause increased pulmonary and cardiovascular morbidity and mortality. The wall structures of airways and alveoli act as a series of structural and functional barriers against inhaled particles. Deposited particles are displaced and come into close association with epithelial cells, macrophages and dendritic cells. The cellular interplay after particle deposition in a triple cell co-culture model of the human airway wall was investigated by laser scanning microscopy. Furthermore, the cellular response was determined by measurement of TNF-alpha. Dendritic cells gained access to the apical side of the epithelium where they sampled particles and interacted with macrophages.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Gehr, Peter and Blank, Fabian

ISSN:

1526-0542

ISBN:

16798602

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

08 Jun 2016 10:39

Publisher DOI:

10.1016/j.prrv.2006.04.169

PubMed ID:

16798602

Web of Science ID:

000243007400024

URI:

https://boris.unibe.ch/id/eprint/18930 (FactScience: 1201)

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