X-ray phase contrast imaging of metallized and non-metallized biological samples

Monnin, Pascal; Hlushchuk, Ruslan; Djonov, Valentin; Meuli, Reto; Valley, Jean-François; Verdun, Francis R (2006). X-ray phase contrast imaging of metallized and non-metallized biological samples. Medical physics, 16(3), pp. 172-8. College Park, Md.: American Association of Physicists in Medicine AAPM

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Imaging of biological samples has been performed with a variety of techniques for example electromagnetic waves, electrons, neutrons, ultrasound and X-rays. Also conventional X-ray imaging represents the basis of medical diagnostic imaging, it remains of limited use in this application because it is based solely on the differential absorption of X-rays by tissues. Coherent and bright photon beams, such as those produced by third-generation synchrotron X-ray sources, provide further information on subtle X-ray phase changes at matter interfaces. This complements conventional X-ray absorption by edge enhancement phenomena. Thus, phase contrast imaging has the potential to improve the detection of structures on images by detecting those structures that are invisible with X-ray absorption imaging. Images of a weakly absorbing nylon fibre were recorded in in-line holography geometry using a high resolution low-noise CCD camera at the ESRF in Grenoble. The method was also applied to improve image contrast for images of biological tissues. This paper presents phase contrast microradiographs of vascular tree casts and images of a housefly. These reveal very fine structures, that remain invisible with conventional absorption contrast only.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
UniBE Contributor:	Hlushchuk, Ruslan, Djonov, Valentin Georgiev
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0094-2405
ISBN:	16986456
Publisher:	American Association of Physicists in Medicine AAPM
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:46
Last Modified:	05 Dec 2022 14:14
PubMed ID:	16986456
Web of Science ID:	000208078400002
URI:	https://boris.unibe.ch/id/eprint/18935 (FactScience: 1206)