Long-term effect of intra-arterial thrombolysis in stroke

Nedeltchev, Krassen; Fischer, Urs; Arnold, Marcel; Ballinari, Pietro; Haefeli, Tobias; Kappeler, Liliane; Brekenfeld, Caspar; Remonda, Luca; Schroth, Gerhard; Mattle, Heinrich P (2006). Long-term effect of intra-arterial thrombolysis in stroke. Stroke, 37(12), pp. 3002-3007. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/01.STR.0000249417.24085.80

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BACKGROUND AND PURPOSE: Thrombolysis has been shown to improve the 3-month outcome of patients with ischemic stroke, but knowledge of the long-term effect of thrombolysis is limited. METHODS: The present study compares the long-term outcome of stroke patients who were treated with intra-arterial thrombolysis (IAT) using urokinase with the outcome of patients treated with aspirin. The modified Rankin Scale (mRS) was used to assess the outcome; 173 patients treated with IAT and 261 patients treated with aspirin from the Bernese Stroke Data Bank were eligible for the study. A matching algorithm taking into account patient age and stroke severity on admission (as measured by the National Institute of Health Stroke Scale [NIHSS]) was used to assemble an IAT and an aspirin group. RESULTS: One hundred and forty-four patients treated with IAT and 147 patients treated with aspirin could be matched and included in the comparative analysis. The median NIHSS score was 14 in each group. At 2 years, 56% of the patients treated with IAT and 42% of the patients treated with aspirin achieved functional independence (mRS, 0 to 2; P=0.037). Clinical outcome was excellent (mRS, 0 to 1) in 40% of the IAT and in 24% of the aspirin patients (P=0.008). Mortality was 23% and 24%, respectively. CONCLUSIONS: The present study provides evidence for a sustained effect of IAT when assessed 2 years after the stroke.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology > Cognitive Psychology, Perception and Methodology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Nedeltchev, Krassen, Fischer, Urs Martin, Arnold, Marcel, Ballinari, Pietro, Haefeli, Tobias, Kappeler, Liliane, Brekenfeld, Caspar, Remonda, Luca, Schroth, Gerhard, Mattle, Heinrich


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

02 Mar 2023 23:22

Publisher DOI:



https://boris.unibe.ch/id/eprint/18962 (FactScience: 1237)

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