Alterations of white matter connectivity in first episode schizophrenia

Federspiel, Andrea; Begré, Stefan; Kiefer, Claus; Schroth, Gerhard; Strik, Werner K; Dierks, Thomas (2006). Alterations of white matter connectivity in first episode schizophrenia. Neurobiology of disease, 22(3), pp. 702-9. Amsterdam: Elsevier 10.1016/j.nbd.2006.01.015

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Cerebral disconnectivity due to white matter alterations in patients with chronic schizophrenia assessed by diffusion tensor imaging has been reported previously. The aim of this preliminary study is to investigate whether cerebral disconnectivity can be detected as early as the first episode of schizophrenia. Intervoxel coherence values were compared by voxel-based t test in 12 patients with first episode schizophrenia and 12 age- and gender-matched control groups. We detected 14 circumscribed significant clusters (P < 0.02), 3 of them with higher, and 11 of them with lower IC values for patients with schizophrenia than for healthy control groups. We interpret these white matter alterations in different regions to be disconnected fiber tracts already present early in schizophrenic disease progression.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued] 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
UniBE Contributor:	Federspiel, Andrea, Begré, Stefan, Kiefer, Claus, Schroth, Gerhard, Strik, Werner, Dierks, Thomas
ISSN:	0969-9961
ISBN:	16624566
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:46
Last Modified:	05 Dec 2022 14:14
Publisher DOI:	10.1016/j.nbd.2006.01.015
PubMed ID:	16624566
Web of Science ID:	000238462600025
URI:	https://boris.unibe.ch/id/eprint/18965 (FactScience: 1241)