Alterations of white matter connectivity in first episode schizophrenia

Federspiel, Andrea; Begré, Stefan; Kiefer, Claus; Schroth, Gerhard; Strik, Werner K; Dierks, Thomas (2006). Alterations of white matter connectivity in first episode schizophrenia. Neurobiology of disease, 22(3), pp. 702-9. Amsterdam: Elsevier 10.1016/j.nbd.2006.01.015

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Cerebral disconnectivity due to white matter alterations in patients with chronic schizophrenia assessed by diffusion tensor imaging has been reported previously. The aim of this preliminary study is to investigate whether cerebral disconnectivity can be detected as early as the first episode of schizophrenia. Intervoxel coherence values were compared by voxel-based t test in 12 patients with first episode schizophrenia and 12 age- and gender-matched control groups. We detected 14 circumscribed significant clusters (P < 0.02), 3 of them with higher, and 11 of them with lower IC values for patients with schizophrenia than for healthy control groups. We interpret these white matter alterations in different regions to be disconnected fiber tracts already present early in schizophrenic disease progression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Federspiel, Andrea; Begré, Stefan; Kiefer, Claus; Schroth, Gerhard; Strik, Werner and Dierks, Thomas

ISSN:

0969-9961

ISBN:

16624566

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1016/j.nbd.2006.01.015

PubMed ID:

16624566

Web of Science ID:

000238462600025

URI:

https://boris.unibe.ch/id/eprint/18965 (FactScience: 1241)

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