Comparison of spatial and temporal pattern for fMRI obtained with BOLD and arterial spin labeling

Federspiel, A; Müller, T J; Horn, H; Kiefer, C; Strik, W K (2006). Comparison of spatial and temporal pattern for fMRI obtained with BOLD and arterial spin labeling. Journal of neural transmission, 113(10), pp. 1403-15. Wien: Springer 10.1007/s00702-006-0434-5

Full text not available from this repository. (Request a copy)

Functional magnetic resonance imaging (fMRI) is presently either performed using blood oxygenation level-dependent (BOLD) contrast or using cerebral blood flow (CBF), measured with arterial spin labeling (ASL) technique. The present fMRI study aimed to provide practical hints to favour one method over the other. It involved three different acquisition methods during visual checkerboard stimulation on nine healthy subjects: 1) CBF contrast obtained from ASL, 2) BOLD contrast extracted from ASL and 3) BOLD contrast from Echo planar imaging. Previous findings were replicated; i) no differences between the three measurements were found in the location of the activated region; ii) differences were found in the temporal characteristics of the signals and iii) BOLD has significantly higher sensitivity than ASL perfusion. ASL fMRI was favoured when the investigation demands for perfusion and task related signal changes. BOLD fMRI is more suitable in conjunction with fast event related design.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Federspiel, Andrea; Müller, Thomas Jörg; Horn, Helge Joachim; Kiefer, Claus and Strik, Werner

ISSN:

0300-9564

ISBN:

16604307

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1007/s00702-006-0434-5

PubMed ID:

16604307

Web of Science ID:

000240797700006

URI:

https://boris.unibe.ch/id/eprint/18966 (FactScience: 1242)

Actions (login required)

Edit item Edit item
Provide Feedback