Muscle metabolites: functional MR spectroscopy during exercise imposed by tetanic electrical nerve stimulation

Nirkko, Arto C; Rösler, Kai M; Slotboom, Johannes (2006). Muscle metabolites: functional MR spectroscopy during exercise imposed by tetanic electrical nerve stimulation. Radiology, 241(1), pp. 235-42. Oak Brook, Ill.: Radiological Society of North America RSNA 10.1148/radiol.2411050487

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Permission from the ethics committee and informed consent were obtained. The purpose of this study was to prospectively evaluate a method developed for the noninvasive assessment of muscle metabolites during exercise. Hydrogen 1 magnetic resonance (MR) spectroscopy peaks were measured during tetanic isometric muscle contraction imposed by supramaximal repetitive nerve stimulation. The kinetics of creatine-phosphocreatine and acetylcarnitine signal changes (P < .001) could be assessed continuously before, during, and after exercise. The control peak (trimethylammonium compounds), which served as an internal reference, did not change. This technique-that is, functional MR spectroscopy-opens the possibility for noninvasive diagnostic muscle metabolite testing in a clinical setting.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Nirkko, Arto C.; Rösler, Kai Michael and Slotboom, Johannes

ISSN:

0033-8419

ISBN:

16928972

Publisher:

Radiological Society of North America RSNA

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1148/radiol.2411050487

PubMed ID:

16928972

Web of Science ID:

000240765100029

URI:

https://boris.unibe.ch/id/eprint/18975 (FactScience: 1251)

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