Ruperti-Repilado, Francisco Javier; Haag, Nora; Fischer, Thomas; Lopes, Bruno Santos; Meier, Lukas; Wustmann, Kerstin; Bonassin, Francesca; Jost, Christine Attenhofer; Schwitz, Fabienne; Schwerzmann, Markus; Tobler, Daniel; Felten, Stefanie Von; Greutmann, Matthias (2023). Impact of pulmonary valve replacement on ventricular function and cardiac events in patients with tetralogy of Fallot. A retrospective cohort study. (In Press). Revista española de cardiología (English ed.) Elsevier 10.1016/j.rec.2023.11.007
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INTRODUCTION AND OBJECTIVES
Our aim was to assess the impact of prosthetic pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot (rTOF) on changes in biventricular volumes and function and on adverse cardiac events.
METHODS
Adults with rTOF were identified from the SACHER-registry. Data from serial cardiac magnetic resonance imaging, echocardiography, exercise capacity and n-terminal pro b-type natriuretic peptide (NT-proBNP) were collected. The primary endpoint was right ventricular ejection fraction (RVEF) as measured by cardiac magnetic resonance. Secondary endpoints were biventricular volumes, left ventricular ejection fraction, exercise capacity and NT-proBNP levels, and time to adverse cardiac outcomes (atrial and ventricular arrhythmia, endocarditis). Associations between previous PVR and longitudinal changes in functional outcomes and time to adverse cardiac outcomes were analyzed using linear mixed-effects models and Cox proportional hazards models, respectively.
RESULTS
A total of 308 patients (153 with and 155 without PVR) with 887 study visits were analyzed. Previous PVR was not significantly associated with changes in RVEF (CE, --1.33; 95%CI, -5.87 to 3.21; P = .566). Previous PVR was associated with lower right ventricular end-diastolic volume but had no significant effect on left ventricular ejection fraction, exercise capacity, or NT-proBNP-levels. Previous PVR was associated with an increased hazard of atrial arrhythmias (HR, 2.09; 95%CI, 1.17-3.72; P = .012) and infective endocarditis (HR, 12.72; 95%CI, 4.69-34.49; P < .0001) but not with an increased hazard of sustained ventricular arrhythmias (HR, 0.64; 95%CI, 0.18-2.27; P = .490).
CONCLUSIONS
Previous PVR was not significantly associated with changes in RVEF but was associated with an increased risk of atrial arrhythmias and infective endocarditis.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Wustmann, Kerstin Brigitte, Schwitz, Fabienne Muriel, Schwerzmann, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1885-5857 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Dec 2023 11:24 |
Last Modified: |
05 Dec 2023 11:33 |
Publisher DOI: |
10.1016/j.rec.2023.11.007 |
PubMed ID: |
38048843 |
Uncontrolled Keywords: |
Cardiovascular complications Complicaciones cardiovasculares Fracción de eyección del ventrículo derecho Pulmonary valve replacement Recambio valvular pulmonar Right ventricular ejection fraction Tetralogy of Fallot Tetralogía de Fallot |
BORIS DOI: |
10.48350/189834 |
URI: |
https://boris.unibe.ch/id/eprint/189834 |
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