Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia

Mueller, B U; Pabst, T; Hauser, P; Gilliland, G; Neuberg, D; Tenen, D G (2006). Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia. British journal of cancer, 94(12), pp. 1918-20. Basingstoke: Nature Publishing Group 10.1038/sj.bjc.6603198

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The transcription factor PU.1 plays a crucial role during normal haematopoiesis in both myeloid cells and B-lymphocytes. Mice with a disruption in both alleles of the PU.1 locus were found to lack macrophages and B cells and had delayed appearance of neutrophils. In addition, critical decrease of PU.1 expression is sufficient to cause acute myeloid leukaemia (AML) and lymphomas in mice. Recently, we reported that heterozygous mutations in the PU.1 gene are present in some patients with AML. Thus, we hypothesised that PU.1 mutations might also contribute to the development of acute leukaemias of the B-cell lineage. Here, we screened 62 patients with B-cell acute lymphoblastic leukaemia (B-ALL) at diagnosis for genomic mutations by direct sequencing of all five exons of the PU.1 gene. We found no genomic alteration of the PU.1 gene suggesting that PU.1 mutations are not likely to be common in B-ALL.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Müller, Beatrice Ursula and Pabst, Thomas

ISSN:

0007-0920

ISBN:

16735999

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

17 Mar 2015 21:45

Publisher DOI:

10.1038/sj.bjc.6603198

PubMed ID:

16735999

Web of Science ID:

000238288000023

URI:

https://boris.unibe.ch/id/eprint/18992 (FactScience: 1353)

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