Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

Gerber, Peter; Stucki, Armin; Acosta, Fernando; Cottagnoud, Marianne; Cottagnoud, Philippe (2006). Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis. Journal of antimicrobial chemotherapy, 57(4), pp. 720-3. Oxford: Oxford University Press 10.1093/jac/dkl007

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OBJECTIVES: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges RESULTS: Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (-4.54 +/- 1.12 log(10)/mL for daptomycin versus -3.43 +/- 1.17 log(10)/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was approximately 5% and approximately 2% into non-inflamed meninges. CONCLUSIONS: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
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04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

Gerber, Peter; Stucki, Andreas Hans and Cottagnoud, Philippe

ISSN:

0305-7453

ISBN:

16459345

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

27 Apr 2018 09:50

Publisher DOI:

10.1093/jac/dkl007

PubMed ID:

16459345

Web of Science ID:

000236105100019

BORIS DOI:

10.7892/boris.19010

URI:

https://boris.unibe.ch/id/eprint/19010 (FactScience: 1375)

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