Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parameters

Stucki, Armin; Gerber, Peter; Acosta, Fernando; Cottagnoud, Marianne; Cottagnoud, Philippe (2006). Efficacy of telavancin against penicillin-resistant pneumococci and Staphylococcus aureus in a rabbit meningitis model and determination of kinetic parameters. Antimicrobial agents and chemotherapy, 50(2), pp. 770-3. Washington, D.C.: American Society for Microbiology 10.1128/AAC.50.2.770-773.2006

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The penetration of telavancin was 2% into inflamed meninges and ca. 1 per thousand into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.

Item Type:

Journal Article (Original Article)

Division/Institute:

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04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

Stucki, Andreas Hans; Gerber, Peter and Cottagnoud, Philippe

ISSN:

0066-4804

ISBN:

16436742

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

06 Dec 2013 13:41

Publisher DOI:

10.1128/AAC.50.2.770-773.2006

PubMed ID:

16436742

Web of Science ID:

000235294200053

URI:

https://boris.unibe.ch/id/eprint/19011 (FactScience: 1376)

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