Groppa, Sergiu; Gonzalez-Escamilla, Gabriel; Tinkhauser, Gerd; Baqapuri, Halim Ibrahim; Sajonz, Bastian; Wiest, Christoph; Pereira, Joana; Herz, Damian M; Dold, Matthias R; Bange, Manuel; Ciolac, Dumitru; Almeida, Viviane; Neuber, John; Mirzac, Daniela; Martín-Rodríguez, Juan Francisco; Dresel, Christian; Muthuraman, Muthuraman; Adarmes Gomez, Astrid D; Navas, Marta; Temiz, Gizem; ... (2024). Perspectives of Implementation of Closed-Loop Deep Brain Stimulation: From Neurological to Psychiatric Disorders. Stereotactic and functional neurosurgery, 102(1), pp. 40-54. Karger 10.1159/000535114
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BACKGROUND
Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy to alleviate symptoms and improve quality of life in movement disorders such as Parkinson's disease, essential tremor, and dystonia, which is also being applied in several psychiatric disorders, such as obsessive-compulsive disorder and depression, when they are otherwise resistant to therapy.
SUMMARY
At present, DBS is clinically applied in the so-called open-loop approach, with fixed stimulation parameters, irrespective of the patients' clinical state(s). This approach ignores the brain states or feedback from the central nervous system or peripheral recordings, thus potentially limiting its efficacy and inducing side effects by stimulation of the targeted networks below or above the therapeutic level.
KEY MESSAGES
The currently emerging closed-loop (CL) approaches are designed to adapt stimulation parameters to the electrophysiological surrogates of disease symptoms and states. CL-DBS paves the way for adaptive personalized DBS protocols. This review elaborates on the perspectives of the CL technology and discusses its opportunities as well as its potential pitfalls for both clinical and research use in neuropsychiatric disorders.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Tinkhauser, Gerd |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1011-6125 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Dec 2023 10:27 |
Last Modified: |
14 Feb 2024 00:14 |
Publisher DOI: |
10.1159/000535114 |
PubMed ID: |
38086346 |
Uncontrolled Keywords: |
Closed loop Deep brain stimulation Electrophysiology Neuroimaging |
BORIS DOI: |
10.48350/190248 |
URI: |
https://boris.unibe.ch/id/eprint/190248 |
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