Meyer, Sara C.; Medinger, Michael; Halter, Jörg P; Baldomero, Helen; Hirsch, Hans H; Tzankov, Alexandar; Dirnhofer, Stephan; Passweg, Jakob R; Tichelli, André (2014). Heterogeneity in clinical course of EBV-associated lymphoproliferative disorder after allogeneic stem cell transplantation. Hematology, 19(5), pp. 280-285. Taylor & Francis 10.1179/1607845413Y.0000000123
Full text not available from this repository. (Request a copy)OBJECTIVE AND IMPORTANCE
Post-transplant lymphoproliferative disorder (PTLD) is a severe complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) associated with Epstein-Barr virus (EBV).
CLINICAL PRESENTATIONS
Among 263 individuals treated with allo-HSCT for severe aplastic anemia, pure white cell aplasia, T-prolymphocytic leukemia, and relapsed Hodgkin lymphoma, we diagnosed EBV-PTLD in 5 patients. Median age was 29 years (range 19-70 years) and four of five patients were EBV-seropositive prior to HSCT. All five had unrelated EBV-positive donors. In all cases, PTLD occurred within the first year post-transplant (median 4 months).
INTERVENTION
There were two rapidly fatal courses with extensive organ involvement. Both patients showed lymphopenia and thrombocytopenia. In contrast, the three surviving patients had higher lymphocytes and normal platelet counts, while PTLD was restricted to one site and resolved after 2-4 cycles of rituximab.
CONCLUSION
In this case series courses of PTLD showed substantial diversity.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Meyer, Sara Christina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1607-8454 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Julia Elisa Garcia |
Date Deposited: |
22 Dec 2023 07:11 |
Last Modified: |
22 Dec 2023 07:11 |
Publisher DOI: |
10.1179/1607845413Y.0000000123 |
PubMed ID: |
24074746 |
Uncontrolled Keywords: |
Epstein–Barr virus Hematopoietic stem cell transplantation Post-transplant lymphoproliferative disorder |
URI: |
https://boris.unibe.ch/id/eprint/190317 |
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