Leemann, Siri; Schneider-Warme, Franziska; Kleinlogel, Sonja (2023). Cardiac optogenetics: shining light on signaling pathways. Pflügers Archiv : European journal of physiology, 475(12), pp. 1421-1437. Springer 10.1007/s00424-023-02892-y
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In the early 2000s, the field of neuroscience experienced a groundbreaking transformation with the advent of optogenetics. This innovative technique harnesses the properties of naturally occurring and genetically engineered rhodopsins to confer light sensitivity upon target cells. The remarkable spatiotemporal precision offered by optogenetics has provided researchers with unprecedented opportunities to dissect cellular physiology, leading to an entirely new level of investigation. Initially revolutionizing neuroscience, optogenetics quickly piqued the interest of the wider scientific community, and optogenetic applications were expanded to cardiovascular research. Over the past decade, researchers have employed various optical tools to observe, regulate, and steer the membrane potential of excitable cells in the heart. Despite these advancements, achieving control over specific signaling pathways within the heart has remained an elusive goal. Here, we review the optogenetic tools suitable to control cardiac signaling pathways with a focus on GPCR signaling, and delineate potential applications for studying these pathways, both in healthy and diseased hearts. By shedding light on these exciting developments, we hope to contribute to the ongoing progress in basic cardiac research to facilitate the discovery of novel therapeutic possibilities for treating cardiovascular pathologies.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology |
UniBE Contributor: |
Leemann, Siri Michelle, Kleinlogel, Sonja |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-2013 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 Dec 2023 10:48 |
Last Modified: |
21 Dec 2023 00:17 |
Publisher DOI: |
10.1007/s00424-023-02892-y |
PubMed ID: |
38097805 |
Uncontrolled Keywords: |
Cardiac optogenetics Cardiac signaling GPCR OptoGPCR |
BORIS DOI: |
10.48350/190386 |
URI: |
https://boris.unibe.ch/id/eprint/190386 |
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