Amiri, Mohammad Amin; Farshidfar, Nima; Miron, Richard J; Dziedzic, Arkadiusz; Hamedani, Shahram; Daneshi, Sajad; Tayebi, Lobat (2023). The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence. International journal of biomaterials, 2023(9980349), p. 9980349. 10.1155/2023/9980349
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Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Miron, Richard John |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1687-8787 |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Dec 2023 09:21 |
Last Modified: |
14 Jan 2024 02:42 |
Publisher DOI: |
10.1155/2023/9980349 |
PubMed ID: |
38098766 |
BORIS DOI: |
10.48350/190419 |
URI: |
https://boris.unibe.ch/id/eprint/190419 |
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