Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization.

Jankovic, Jana; Tièche, Eve; Dettwiler, Martina; Hahn, Kerstin; Scheemaeker, Stephanie; Kessler, Martin; Daminet, Sylvie; Rottenberg, Sven; Campos, Miguel (2024). Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization. Veterinary pathology, 61(4), pp. 524-533. Sage 10.1177/03009858231217245

Full text not available from this repository.

Research on modulation of iodine uptake by thyroid cells could help improve radioiodine treatment of dogs with thyroid tumors. The aim of this study was to characterize the immunohistochemical expression of thyroid transcription factor-1 (TTF-1), thyroglobulin, thyrotropin receptor (TSHR), sodium iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), vimentin, and Ki-67 in follicular cell thyroid carcinomas (FTCs) and medullary thyroid carcinomas (MTCs), and to compare protein expression between FTC causing hyperthyroidism and FTC of euthyroid dogs. Immunohistochemistry was performed in 25 FTCs (9 follicular, 8 follicular-compact, and 8 compact) and 8 MTCs. FTCs and MTCs were positive for TTF-1, and expression was higher in FTCs of euthyroid dogs compared with FTCs of hyperthyroid dogs (P= .041). Immunolabeling for thyroglobulin was higher in follicular and follicular-compact FTCs compared with compact FTCs (P = .001), while vimentin expression was higher in follicular-compact FTCs compared with follicular FTCs (P = .011). The expression of TSHR, NIS, pendrin, and TPO was not significantly different among the different subtypes of FTCs or between FTCs causing hyperthyroidism and FTCs in euthyroid dogs. TSHR, NIS, pendrin, and TPO were also expressed in MTCs. Ki-67 labeling index was comparable between FTCs and MTCs, and between FTCs causing hyperthyroidism and FTCs in euthyroid dogs. Proteins of iodine transport were also expressed in canine MTCs, which could have implications for diagnosis and treatment. The different expression of thyroglobulin and vimentin between FTC histological subtypes could reflect variations in tumor differentiation.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
UniBE Contributor:	Tièche, Eve Saphir, Dettwiler, Martina Andrea, Hahn, Kerstin Caroline, Rottenberg, Sven, Campos, Miguel
Subjects:	600 Technology > 630 Agriculture
ISSN:	1544-2217
Publisher:	Sage
Language:	English
Submitter:	Pubmed Import
Date Deposited:	18 Dec 2023 15:02
Last Modified:	02 Jul 2024 00:12
Publisher DOI:	10.1177/03009858231217245
PubMed ID:	38098215
Uncontrolled Keywords:	dogs follicular cell thyroid carcinoma immunohistochemistry iodine uptake medullary thyroid carcinoma pendrin sodium iodide symporter thyroid peroxidase thyroid-stimulating hormone receptor
URI:	https://boris.unibe.ch/id/eprint/190421