Neural complexity and the spectral slope characterise auditory processing in wakefulness and sleep.

Alnes, Sigurd L; Bächlin, Lea Z M; Schindler, Kaspar; Tzovara, Athina (2024). Neural complexity and the spectral slope characterise auditory processing in wakefulness and sleep. European journal of neuroscience, 59(5), pp. 822-841. Wiley 10.1111/ejn.16203

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Auditory processing and the complexity of neural activity can both indicate residual consciousness levels and differentiate states of arousal. However, how measures of neural signal complexity manifest in neural activity following environmental stimulation and, more generally, how the electrophysiological characteristics of auditory responses change in states of reduced consciousness remain under-explored. Here, we tested the hypothesis that measures of neural complexity and the spectral slope would discriminate stages of sleep and wakefulness not only in baseline electroencephalography (EEG) activity but also in EEG signals following auditory stimulation. High-density EEG was recorded in 21 participants to determine the spatial relationship between these measures and between EEG recorded pre- and post-auditory stimulation. Results showed that the complexity and the spectral slope in the 2-20 Hz range discriminated between sleep stages and had a high correlation in sleep. In wakefulness, complexity was strongly correlated to the 20-40 Hz spectral slope. Auditory stimulation resulted in reduced complexity in sleep compared to the pre-stimulation EEG activity and modulated the spectral slope in wakefulness. These findings confirm our hypothesis that electrophysiological markers of arousal are sensitive to sleep/wake states in EEG activity during baseline and following auditory stimulation. Our results have direct applications to studies using auditory stimulation to probe neural functions in states of reduced consciousness.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Computer Science (INF) > Cognitive Computational Neuroscience (CCN)
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
08 Faculty of Science > Institute of Computer Science (INF)

UniBE Contributor:

Alnes, Sigurd Lerkerød, Schindler, Kaspar Anton, Tzovara, Athina

Subjects:

000 Computer science, knowledge & systems
600 Technology > 610 Medicine & health
500 Science > 510 Mathematics
600 Technology > 620 Engineering

ISSN:

1460-9568

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

18 Dec 2023 10:21

Last Modified:

19 Mar 2024 00:13

Publisher DOI:

10.1111/ejn.16203

PubMed ID:

38100263

Uncontrolled Keywords:

EEG auditory stimulation neural complexity sleep and wakefulness spectral slope

BORIS DOI:

10.48350/190434

URI:

https://boris.unibe.ch/id/eprint/190434

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