Wurm, Juliane; Uka, Anita; Bernet, Vera; Buettcher, Michael; Giannoni, Eric; Kottanattu, Lisa; Schöbi, Nina; Zemmouri, Abdelaziz; Ritz, Nicole; Zimmermann, Petra (2024). The changing clinical presentation of COVID-19 in children during the course of the pandemic. Acta paediatrica, 113(4), pp. 771-777. Wiley 10.1111/apa.17061
|
Text
Acta_Paediatrica_-_2023_-_Wurm_-_The_changing_clinical_presentation_of_COVID_19_in_children_during_the_course_of_the.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (4MB) | Preview |
AIM
To investigate the evolution of clinical symptoms of COVID-19 in children throughout the pandemic.
METHODS
In this national prospective surveillance study, symptoms in children hospitalised with COVID-19 were collected from all paediatric hospitals in Switzerland between March 2020 and March 2023. Data was analysed across four time periods, according to the predominantly circulating SARS-CoV-2 variant: T1 (wild-type), T2 (Alpha), T3 (Delta) and T4 (Omicron), as well as by age group.
RESULTS
The study included 1323 children. The proportion of children admitted to an intensive care unit remained stable throughout the pandemic. However, the pattern and frequency of clinical manifestations changed over time. Respiratory symptoms were less prevalent during T1 (wild-type), fever during T2 (Alpha) and rash during T4 (Omicron). In contrast, fever and neurological symptoms were more prevalent during T4 (Omicron). Newly described symptoms during T4 (Omicron) included conjunctivitis, laryngotracheitis and seizures. Fever was more prevalent among neonates and infants whereas respiratory symptoms were more common among infants. Gastrointestinal symptoms were more frequent among toddlers, while both toddlers and school-aged children presented with neurological symptoms more often than other age groups.
CONCLUSION
Continuous surveillance is required to detect changes in manifestations and there by be prepared for the optimal management of complications in children with COVID-19.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology |
UniBE Contributor: |
Schöbi, Nina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1651-2227 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
18 Dec 2023 10:14 |
Last Modified: |
12 Mar 2024 00:14 |
Publisher DOI: |
10.1111/apa.17061 |
PubMed ID: |
38102898 |
Uncontrolled Keywords: |
Alpha Delta Omicron SARS-CoV-2 gastrointestinal rash seizure variants |
BORIS DOI: |
10.48350/190437 |
URI: |
https://boris.unibe.ch/id/eprint/190437 |
Actions (login required)
 |
Edit item |