Effect of donor-specific transfusions on the outcome of renal allografts in the cyclosporine era

Marti, Hans-Peter; Henschkowski, Jana; Laux, Gunter; Vogt, Bruno; Seiler, Christian; Opelz, Gerhard; Frey, Felix J (2006). Effect of donor-specific transfusions on the outcome of renal allografts in the cyclosporine era. Transplant international, 19(1), pp. 19-26. Oxford: Wiley-Blackwell 10.1111/j.1432-2277.2005.00233.x

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Despite the introduction of new immunosuppressive agents, a steady decline of functioning renal allografts after living donation is observed. Thus nonpharmacological strategies to prevent graft loss have to be reconsidered, including donor-specific transfusions (DST). We introduced a cyclosporine-based DST protocol for renal allograft recipients from living-related/unrelated donation. From 1993 to 2003, 200 ml of whole blood, or the respective mononuclear cells from the potential living donor were administered twice to all of our 61 recipient candidates. The transplanted subjects were compared with three groups of patients without DST from the Collaborative Transplant Study (Heidelberg, Germany) during a 6-year period. Six patients were sensitized without delay for a subsequent cadaveric kidney. DST patients had less often treatment for rejection and graft survival was superior compared with subjects from the other Swiss transplant centers (n = 513) or from Western Europe (n = 7024). To diminish the probability that superior results reflect patient selection rather than effects of DST, a 'matched-pair' analysis controlling for relevant factors of transplant outcome was performed. Again, this analysis indicated that recipients with DST had better outcome. Thus, our observation suggests that DST improve the outcome of living kidney transplants even when modern immunosuppressive drugs are prescribed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Marti, Hans-Peter; Seiler, Christian and Frey, Felix Julius

ISSN:

0934-0874

ISBN:

16359373

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

06 Dec 2013 13:41

Publisher DOI:

10.1111/j.1432-2277.2005.00233.x

PubMed ID:

16359373

Web of Science ID:

000235392200004

URI:

https://boris.unibe.ch/id/eprint/19054 (FactScience: 1422)

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