Oltra, Javier; Habich, Annegret; Schwarz, Christopher G; Nedelska, Zuzana; Przybelski, Scott A; Inguanzo, Anna; Diaz-Galvan, Patricia; Lowe, Val J; Oppedal, Ketil; Gonzalez, Maria C; Philippi, Nathalie; Blanc, Frederic; Barkhof, Frederik; Lemstra, Afina W; Hort, Jakub; Padovani, Alessandro; Rektorova, Irena; Bonanni, Laura; Massa, Federico; Kramberger, Milica G; ... (2024). Sex differences in brain atrophy in dementia with Lewy bodies. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(3), pp. 1815-1826. 10.1002/alz.13571
|
Text
Alzheimer_s___Dementia_-_2023_-_Oltra_-_Sex_differences_in_brain_atrophy_in_dementia_with_Lewy_bodies.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (1MB) | Preview |
INTRODUCTION
Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI).
METHODS
We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males).
RESULTS
We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex.
DISCUSSION
We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75.
HIGHLIGHTS
Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Habich, Annegret, Dierks, Thomas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1552-5279 |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Dec 2023 13:11 |
Last Modified: |
16 Mar 2024 00:13 |
Publisher DOI: |
10.1002/alz.13571 |
PubMed ID: |
38131463 |
Uncontrolled Keywords: |
atrophy dementia with Lewy bodies magnetic resonance imaging sex differences |
BORIS DOI: |
10.48350/190733 |
URI: |
https://boris.unibe.ch/id/eprint/190733 |
Actions (login required)
 |
Edit item |