Postoperative RNFL-Changes after Successful Trabeculectomy: 2-Year Outcomes.

Bormann, Caroline; Busch, Catharina; Rehak, Matus; Scharenberg, Christian Thomas; Furashova, Olga; Ziemssen, Focke; Unterlauft, Jan Darius (2024). Postoperative RNFL-Changes after Successful Trabeculectomy: 2-Year Outcomes. Klinische Monatsblätter für Augenheilkunde, 241(6), pp. 772-779. Thieme 10.1055/a-2206-1297

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BACKGROUND

The most important tool in glaucoma therapy is to lower the intraocular pressure to slow down the apoptosis of retinal ganglion cells. Trabeculectomy (TE) is considered the gold standard in glaucoma surgery. The aim of this study was to analyse the postoperative changes in retinal nerve fibre layer (RNFL) using optical coherence tomography (OCT) after TE.

MATERIAL AND METHODS

We examined 40 patients naïve to prior glaucoma surgery retrospectively, who received a TE for medically uncontrolled primary open-angle glaucoma (POAG). Intraocular pressure (IOP), IOP-lowering medication, mean deviation of perimetry, visual acuity and peripapillary RNFL-thickness using OCT were evaluated during the first 24 month after TE.

RESULTS

In total 40 eyes from 40 patients were treated with TE. Mean IOP decreased from 25.0 ± 0,9 to 13.9 ± 0.6 (p < 0.01), and the mean number of IOP-lowering eye drops from 3.3 ± 0.2 to 0.5 ± 0.2 (p < 0.01). Visual acuity and mean deviation in perimetry remained stable while mean global RNFL-thickness decreased from 67.8 ± 2.9 to 63.7 ± 2.9 (p < 0.01) and 63.4 ± 2.9 µm (p < 0.01) 12 and 24 months after TE.

CONCLUSION

The TE is an effective method to reduce the IOD and the amount of IOP-lowering medication. Nevertheless, a significant further loss in RNFL thickness was observed in the first 12 months after TE. Thus, RNFL changes seem to stabilise only after a protracted period.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
UniBE Contributor:	Unterlauft, Jan Darius
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1439-3999
Publisher:	Thieme
Language:	English
Submitter:	Pubmed Import
Date Deposited:	03 Jan 2024 16:55
Last Modified:	30 Jun 2024 00:12
Publisher DOI:	10.1055/a-2206-1297
PubMed ID:	38134909
URI:	https://boris.unibe.ch/id/eprint/190761