Hermans, L E; Centner, C M; Morel, C M; Mbamalu, O; Bonaconsa, C; Ferreyra, C; Lindahl, O; Mendelson, M (2024). Point-of-Care Diagnostics for Infection and Antimicrobial Resistance in Sub-Saharan Africa - A Narrative Review. International journal of infectious diseases, 142, p. 106907. Elsevier 10.1016/j.ijid.2023.11.027
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INTRODUCTION
Sub-Saharan African (SSA) countries are severely impacted by antimicrobial resistance (AMR). Due to gaps in access to diagnostics in SSA the true extent of AMR remains unknown. This diagnostic gap affects patient management and leads to significant antimicrobial overuse. This review explores how point-of-care (POC) testing for pathogen identification and AMR may be used to close the diagnostic gap in SSA countries.
METHODS
A narrative review exploring current clinical practice and novel developments in the field of point-of-care (POC) testing for infectious diseases and AMR.
FINDINGS
POC assays for identification of various pathogens have been successfully rolled out in SSA countries. While implementation studies have mostly highlighted impressive test performance of POC assays, there is limited data on effect of implementation on clinical outcomes and cost-effectiveness. We did not encounter local studies of host-directed POC assays relevant to AMR. Novel POC assays using real-time PCR, isothermal amplification, microfluidics and other technologies are in various stages of development.
DISCUSSION
Available literature shows that POC testing for AMR applications is implementable in SSA and holds the potential to reduce the diagnostic gap. Implementation will require effective regulatory pathways, incorporation of POC testing in clinical and laboratory guidelines, and adequate value capture in existing health financing models.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
11 Centers of Competence > KPM Center for Public Management |
UniBE Contributor: |
Morel, Chantal Marie Marie-S. |
Subjects: |
300 Social sciences, sociology & anthropology > 350 Public administration & military science |
ISSN: |
1878-3511 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Dec 2023 14:41 |
Last Modified: |
16 Apr 2024 00:13 |
Publisher DOI: |
10.1016/j.ijid.2023.11.027 |
PubMed ID: |
38141961 |
BORIS DOI: |
10.48350/190762 |
URI: |
https://boris.unibe.ch/id/eprint/190762 |
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