Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19.

Jurisic, Stjepan; Komminoth, Mathis; Todorov, Atanas; Bertschi, Daniela A; Jurisic, Martin; Vranjic, Ivica; Wiggli, Benedikt; Schmid, Hansruedi; Gebhard, Catherine; Gebhard, Caroline E; Heidecker, Bettina; Beer, Jürg-Hans; Patriki, Dimitri (2023). Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19. Journal of clinical medicine, 12(8) MDPI 10.3390/jcm12082925

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Background: Atrial fibrillation (AF) has been described as a common cardiovascular manifestation in patients suffering from coronavirus disease 2019 (COVID-19) and has been suggested to be a potential risk factor for a poor clinical outcome. Methods: In this observational study, all patients hospitalized due to COVID-19 in 2020 in the Cantonal Hospital of Baden were included. We assessed clinical characteristics, in-hospital outcomes as well as long-term outcomes with a mean follow-up time of 278 (±90) days. Results: Amongst 646 patients diagnosed with COVID-19 (59% male, median age: 70 (IQR: 59-80)) in 2020, a total of 177 (27.4%) patients were transferred to the intermediate/intensive care unit (IMC/ICU), and 76 (11.8%) were invasively ventilated during their hospitalization. Ninety patients (13.9%) died. A total of 116 patients (18%) showed AF on admission of which 34 (29%) had new-onset AF. Patients with COVID-19 and newly diagnosed AF were more likely to require invasive ventilation (OR: 3.5; p = 0.01) but did not encounter an increased in-hospital mortality. Moreover, AF neither increased long-term mortality nor the number of rehospitalizations during follow-up after adjusting for confounders. Conclusions: In patients suffering from COVID-19, the new-onset of AF on admission was associated with an increased risk of invasive ventilation and transfer to the IMC/ICU but did not affect in-hospital or long-term mortality.

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